DMAE is an amazing nutrient that extends the life of cells, inhibits the cross linking of proteins, which gives the skin a tone and firm appearance. The MSM & DMAE serum we offer is very light and can be put on over or under the makeup. We also use a hefty dose of DMAE in our Skin Renewal Intensive Facial Cream. The firm appearance that DMAE can bring to the skin occurs within about 20 minutes and wears off by the end of the day. DMAE has become very popular as a result of Dr. Nicholas Perricone, M.D.’s top-selling book, The Wrinkle Cure, in which he promotes supplementing with DMAE as a treatment for reducing wrinkles. When applied to the skin DMAE would stimulate acetylcholine release which would trigger a response in the muscles of the face. This activity creates a firmer facial tone and less sagging.

DMAE is one of the few nutrients that research studies have shown to extend the life of cells, but DMAE levels decrease dramatically with age. DMAE stabilizes the cell’s membrane and boosts the effects of other antioxidants. However, the main reason for adding DMAE to the Wrinkle Serum is due to its high level of acetylcholine, necessary for skin tone and firmness. When DMAE is applied topically it begins to work quickly (within minutes of application) and continues to firm and tone the skin over time.

Further information: dimethylaminoethanol (DMAE) seems to improve the firmness of the skin and to help reduce the visual appearance of sagging skin (cutis laxa). DMAE is an amine-based alcohol, a precursor to the neurotransmitter acetylcholine, DMAE is present in nerve tissue in small amounts and more abundant in fish. DMAE would act as a free radical scavenger due to the high electron content of its nitrogen atom. Once phosphorylated, DMAE is incorporated into the membrane of cells, protecting against the cell membrane protein cross-linking. In addition, DMAE is an immediate precursor to choline, which is involved in cell membrane biosynthesis. % DMAE facial gel applied daily for 16 weeks has been shown to be safe and efficacious in mitigating forehead lines and periorbital fine wrinkles, and in improving lip shape and fullness and the overall appearance of aging skin.

References: Uhoda I.; Faska N.; Robert C.; Cauwenbergh G.; Pierard G. (2002) “Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel.” Skin research and technology 8(3), 164-7.

Grossman R. (2005) “The role of dimethylaminoethanol in cosmetic dermatology”. American journal of clinical dermatology 6(1), 39-47.